TARGETED
GENE THERAPY
To transform the lives of people living with
severe and life-threatening diseases
Combining cutting edge science, experienced business leaders and innovators, Regel Therapeutics is committed to leveraging its proprietary platform technology to revolutionize gene therapy and change patient outcomes across multiple indications
Work with us
We are looking for highly-qualified and passionate
professionals to join our team
Regel Therapeutics is a gene modulation therapy company focused on improving the life of patients suffering from disorders resulting from alteration of gene expression. Our proven T3 (Targeted Therapeutic Technology) platform combines AAV delivery with two proprietary technologies for efficient and specific restoration of gene expression exclusively in the cells affected by the pathology. We are a seed-stage startup based in Cambridge, MA and Berkeley, CA and we are looking for a talented Research Associate to join our R&D team to help develop our preclinical programs.
Location
Berkeley, CA
Role Responsibilities
- Implement in vitro screening methodology with guidance from senior scientists
- Assemble and validate screening constructs
- Maintain mammalian cell cultures and perform transfections for high throughput screening
- Perform molecular techniques including nucleic acid extraction, PCR, RT-PCR, etc.
- Maintain organized and detailed documentation of activities in an electronic notebook
- Communicate research findings to the R&D team
Required Qualifications
- BA/BS or MS in biology, neurobiology or related field with 1-3 years relevant research experience
- Extensive experience with standard molecular biology techniques (PCR, qPCR, DNA/RNA extraction), and molecular cloning techniques (RE digestion, ligation/gibson assembly, transformation, plasmid preparation and purification)
- Strong background in mammalian cell culture and aseptic technique
- Excellent written and oral communication skills
- Proven track record of working in collaborative environments
Preferred Qualifications
- Experience with transfection protocols
- Familiarity with CRISPR-Cas system
- Familiarity with qPCR and luciferase analysis
Regel Therapeutics is a gene modulation therapy company focused on improving the life of patients suffering from disorders resulting from alteration of gene expression. Our proven T3 (Targeted Therapeutic Technology) platform combines AAV delivery with two proprietary technologies for efficient and specific restoration of gene expression exclusively in the cells affected by the pathology. We are a seed-stage startup based in Cambridge, MA and Berkeley, CA and we are looking for a talented Laboratory Operations Manager to support our scientific operations.
Location
Berkeley, CA
Role Responsibilities
- Maintain inventory of all supplies and reagents
- Track and maintain records of monthly expenses
- Manage relationships with vendors, facilities, and partners
- Assist with onboarding/training of new employees
- Prepare and maintain stock of common solutions/reagents
- Maintain cleanliness & organization of lab space
- Coordinate team meetings & events
Required Qualifications
- BA/BS or MS in life sciences-related field with 2+ years of operations experience in a laboratory/biotech setting
- Familiarity with equipment/reagents/supplies used in molecular biology, cloning, tissue culture workflows
- Excellent written and oral communication skills
- Exceptional organizational skills
- Proven track record of working in collaborative environments
Preferred Qualifications
- Previous experience as an operations/lab manager in a large academic laboratory and/or biotech company
Regel Therapeutics is a gene modulation therapy company focused on improving the life of patients suffering from disorders resulting from alteration of gene expression. Our proven T3 (Targeted Therapeutic Technology) platform combines AAV delivery with two proprietary technologies for efficient and specific restoration of gene expression exclusively in the cells affected by the pathology. We are a seed-stage startup based in Cambridge, MA and Berkeley, CA and we are looking for a talented Research Scientist to join our R&D team to help develop our preclinical programs.
Location
Berkeley, CA
Role Responsibilities
- Design and execute molecular cloning strategies in support of Regel’s R&D and preclinical operations
- Maintain oversight of all molecular cloning and viral production efforts across the organization, including coordination with external partners/vendors
- Manage a team of Research Associates to carry out the molecular cloning and viral production needs of the organization
- Formulate and implement strategies to improve viral production yields and quality, including development of QC assays
- Analyze experimental results and formulate conclusions for presentation to the scientific leadership
- Maintain accurate and detailed documentation of activities
Required Qualifications
- PhD in molecular biology, virology, neurobiology, or related field
- Strong background in advanced molecular cloning techniques (i.e. multi-fragment gibson/golden-gate assembly, generation of high-complexity plasmid libraries)
- Familiarity with molecular cloning softwares such as SnapGene and/or Benchling
- Experience producing research-grade viruses including AAV and lentivirus
- Experience with mammalian cell culture methods (i.e. transfection/transduction, FACS)
- Excellent written and oral communication skills
- Proven track record of working in collaborative environments
Preferred Qualifications
- Background in neuroscience/neurobiology or muscle/cardiovascular biology
- Previous experience working with AAVs and lentiviruses for in vivo applications
- Previous experience with long read sequencing & ddPCR
Regel Therapeutics is a gene modulation therapy company focused on improving the life of patients suffering from disorders resulting from alteration of gene expression. Our proven T3 (Targeted Therapeutic Technology) platform combines AAV delivery with two proprietary technologies for efficient and specific restoration of gene expression exclusively in the cells affected by the pathology. We are a seed-stage startup based in Cambridge, MA and Berkeley, CA and we are looking for a talented Research Associate to join our R&D team to help develop our preclinical programs.
Location
Cambridge, MA
Role Responsibilities
- Perform proof-of-concept experiments in cell lines to support preclinical development efforts
- Maintain precious human induced pluripotent stem cell cultures and perform complex differentiation protocols
- Implement in vitro screening and validation methodology
- Analyze experimental results and communicate research findings to leadership
- Maintain accurate and detailed documentation of activities
Required Qualifications
- B.S./M.S. in cellular biology, developmental biology, molecular biology, or related field
- Strong molecular biology skills including DNA/RNA extraction, qPCR, and molecular cloning
- Experience with mammalian cell culture methods and sterile technique
- Experience with cell biology techniques including immunofluorescence staining and microscopy
- Excellent written and oral communication skills
- Proven track record of working in collaborative environments and in a team
Preferred Qualifications
- Experience with pluripotent stem cell differentiation protocols using organoids
- Experience producing libraries for bulk or single cell RNA sequencing
- Basic computational biology skills to interpret differential expression analysis
- Background in neuroscience/neurobiology or muscle/cardiovascular biology
- Previous experience working with AAVs and lentiviruses
Regel Therapeutics is a gene modulation therapy company focused on improving the life of patients suffering from disorders resulting from alteration of gene expression. Our proven T3 (Targeted Therapeutic Technology) platform combines AAV delivery with two proprietary technologies for efficient and specific restoration of gene expression exclusively in the cells affected by the athology. We are a seed-stage startup based in Cambridge, MA and Berkeley, CA and we are looking for a talented Research Scientist to join our R&D team to help develop our preclinical programs.
Location
Cambridge, MA
Role Responsibilities
- Perform proof-of-concept experiments to support preclinical development efforts
- Develop protocols for patient-derived pluripotent stem cell maintenance and differentiation
- Evaluate efficacy and efficiency of differentiation protocols
- Implement in vitro screening and validation methodology
- Clear communication of experimental planning, timeline, and obstacles to project lead
- Analyze experimental results and communicate research findings to leadership
- Maintain accurate and detailed documentation of activities
Required Qualifications
- PhD in cell biology, developmental biology, molecular biology, or related field
- Background in skeletal muscle/cardiovascular biology
- Significant experience with human pluripotent stem cell culture, maintenance, and differentiation
- Expertise in mammalian cell culture techniques including FACS, IF, and ELISA/MSD
- Strong molecular biology skills including DNA/RNA extraction, qPCR, and molecular cloning
- Competence in experimental design and troubleshooting
- Excellent written and oral communication skills & proven track record of working in collaborative environments
Preferred Qualifications
- Expertise in cell electrophysiology or multi-electrode array systems
- Experience producing libraries for bulk or single cell RNA sequencing
- Basic computational biology skills to interpret differential expression analysis
- Previous experience working with AAVs and lentiviruses
Regel Therapeutics is a gene modulation therapy company focused on improving the life of patients suffering from disorders resulting from alteration of gene expression. Our proven T3 (Targeted Therapeutic Technology) platform combines AAV delivery with two proprietary technologies for efficient and specific restoration of gene expression exclusively in the cells affected by the athology. We are a seed-stage startup based in Cambridge, MA and Berkeley, CA and we are looking for a talented Research Scientist to join our R&D team to help develop our preclinical programs.
Location
Berkeley, CA
Role Responsibilities
- Design, optimize, and implement high throughput screens, such as pooled single-cell CRISPR screens and MPRAs, for in vitro and/or in vivo applications
- Execute single cell sequencing experiments, including tissue/cell/nuclei prep and NGS library preparation
- Analyze experimental results, including single-cell and NGS datasets, and formulate conclusions for presentation to the scientific leadership
- Maintain accurate and detailed documentation of activities
Required Qualifications
- PhD in molecular biology, genetics/genomics, neurobiology, or related field
- Strong background in high-throughput molecular screening methodologies (i.e. CRISPR screening, MPRA)
- Experience producing and analyzing single-cell genomics libraries (scRNA-seq and/or scATAC-seq)
- Experience with mammalian cell culture methods (i.e. transfection/transduction, FACS)
- Excellent written and oral communication skills
- Proven track record of working in collaborative environments
Preferred Qualifications
- Strong background in computational biology/bioinformatics
- Background in neuroscience/neurobiology or muscle/cardiovascular biology
- Previous experience working with AAVs and lentiviruses
- Previous experience processing tissues from in vivo experiments