TARGETED
GENE THERAPY

To transform the lives of people living with
severe and life-threatening diseases

Combining cutting edge science, experienced business leaders and innovators, Regel Therapeutics is committed to leveraging its proprietary platform technology to revolutionize gene therapy and change patient outcomes across multiple indications

Work with us

We are looking for highly-qualified and passionate
professionals to join our team

Regel Therapeutics is a gene modulation therapy company focused on improving the life of patients suffering from disorders resulting from alteration of gene expression. Our proven T3 (Targeted Therapeutic Technology) platform combines AAV delivery with two proprietary technologies for efficient and specific restoration of gene expression exclusively in the cells affected by the pathology. We are a seed-stage startup based in Cambridge, MA and Berkeley, CA and we are looking for a talented Research Scientist to join our R&D team to help develop our preclinical programs.

Location

Cambridge, MA

Role Responsibilities

  • Perform proof-of-concept experiments to support preclinical development efforts
  • Manage work performed by external contract research organizations
  • Implement in vitro screening and validation methodology
  • Analyze experimental results and communicate research findings to leadership
  • Maintain accurate and detailed documentation of activities

Required Qualifications

  • PhD in molecular biology, neurobiology, or related field
  • Strong molecular biology skills including DNA/RNA extraction, qPCR, and molecular cloning
  • Experience with mammalian cell culture methods
  • Experience with cell biology techniques including immunocytochemistry and Western blot
  • Excellent written and oral communication skills
  • Proven track record of working in collaborative environments

Preferred Qualifications

  • Experience producing and analyzing single-cell genomics libraries (scRNA-seq and/or scATAC-seq)
  • Background in neuroscience/neurobiology or muscle/cardiovascular biology
  • Previous experience working with AAVs and lentiviruses
Apply Here

Regel Therapeutics is an early-stage startup based in Cambridge, MA and San Francisco, CA that is pioneering precision gene therapies. We are currently looking for a talented Research Associate to join our R&D team under the guidance of senior scientists. Joining at this early stage provides the opportunity to help shape our research aims and company culture.

Location

Cambridge, MA

Role Responsibilities

  • Establish and implement in vitro validation methodology
  • Perform proof-of-concept using molecular biology and histological techniques
  • Participate in experimental design
  • Maintain accurate and detailed documentation of activities
  • Communicate research findings to leadership

Required Qualifications

  • BA/BS/MS in biology, molecular biology, or related field with 2-3 years research experience
  • Strong background in the culture, maintenance, and differentiation of stem cells/iPSCs
  • Experience with cell biology techniques including immunocytochemistry and Western blot
  • Experience in molecular biology skills including DNA/RNA extraction, qPCR, and molecular cloning
  • Excellent written and oral communication skills
  • Proven track record of working in collaborative environments

Preferred Qualifications

  • Background in neurobiology
  • Previous experience working with viruses
Apply Here

Regel Therapeutics is a seed-stage startup based in Cambridge, MA and San Francisco, CA that is pioneering precision gene therapies. We are currently looking for a talented Research Scientist to join our R&D team. Joining at this early stage provides the opportunity to help shape our research aims and company culture.

Location

Cambridge, MA

Role Responsibilities

  • Establish and implement in vitro screening and validation methodology
  • Perform proof-of-concept experiments to support preclinical development efforts
  • Manage work performed by external contract research organizations
  • Work with computational collaborators to analyze experimental results
  • Maintain accurate and detailed documentation of activities
  • Communicate research findings to leadership

Required Qualifications

  • PhD in stem cell biology, neurobiology, or related field
  • Strong expertise in iPSC culture, differentiation, and maintenance
  • Experience with cell biology techniques including immunocytochemistry and Western blot
  • Experience in molecular biology skills including DNA/RNA extraction, qPCR, and molecular cloning
  • Excellent written and oral communication skills
  • Proven track record of working in collaborative environments

Preferred Qualifications

  • Background in neuroscience/neurobiology
  • Previous experience producing and analyzing single-cell genomics data
  • Previous experience working with viruses
Apply Here

Regel Therapeutics is an early-stage startup based in Cambridge, MA and Berkeley, CA that is pioneering precision gene therapies. We are currently looking for a talented Research Associate to join our R&D team under the guidance of senior scientists. Joining at this early stage provides the opportunity to help shape our research aims and company culture.

Location

Berkeley, CA

Role Responsibilities

  • Implement in vitroscreening methodology with guidance from senior scientists
  • Design, assemble, and validate screening constructs
  • Maintain human cell cultures
  • Perform molecular techniques including nucleic acid extraction, qPCR, NGS library prep
  • Produce, purify and titer AAV and lentivirus
  • Maintain accurate and detailed documentation of activities
  • Communicate research findings to the R&D team

Required Qualifications

  • BA/BS or MS in biology, neurobiology or related field with 2-3 years relevant research experience
  • Strong background in tissue culture and aseptic techniques
  • Significant experience with standard molecular biology techniques (PCR, qPCR, DNA/RNA extraction), and molecular cloning techniques (ligation, transformation, gibson, RE digestion)
  • Excellent written and oral communication skills
  • Proven track record of working in collaborative environments

Preferred Qualifications

  • Experience in Lentivirus and AAV production and purification
  • Experience with large-scale genetic screening methods
  • Experience with single-cell genomics techniques and analysis
Apply Here

Regel Therapeutics is a seed-stage startup based in Cambridge, MA and San Francisco, CA that is pioneering precision gene therapies. We are currently looking for a talented Research Scientist to join our R&D team. Joining at this early stage provides the opportunity to help shape our research aims and company culture.

Location

Berkeley, CA

Role Responsibilities

  • Establish and implement in vitro screening and validation methodology
  • Establish and implement AAV production and purification pipeline
  • Perform proof-of-concept experiments to support preclinical development efforts
  • Work with computational collaborators to analyze experimental results
  • Maintain accurate and detailed documentation of activities
  • Communicate research findings to leadership

Required Qualifications

  • PhD in neurobiology, cellular/molecular biology, genetics/genomics, or related field
  • Strong expertise in mammalian cell culture, maintenance, and manipulation (transfection, transduction, FACS)
  • Experience with molecular biology techniques including molecular cloning (vector design and assembly), DNA/RNA extraction, qPCR, and NGS library prep
  • Experience with viral production and purification (AAV, lentivirus)
  • Excellent written and oral communication skills
  • Proven track record of working in collaborative environments

Preferred Qualifications

  • Background in neuroscience/neurobiology
  • Experience with large-scale genetic screening methods
  • Experience producing and analyzing single-cell genomics data
  • Experience with gene editing/modulation technologies (CRISPR, ZFN, TALEN)
Apply Here