TARGETED
GENE THERAPY
To transform the lives of people living with
severe and life-threatening diseases
Combining cutting edge science, experienced business leaders and innovators, Regel Therapeutics is committed to leveraging its proprietary platform technology to revolutionize gene therapy and change patient outcomes across multiple indications
Work with us
We are looking for highly-qualified and passionate
professionals to join our team
Regel Therapeutics is an early-stage startup based in Cambridge, MA and Berkeley, CA that is pioneering precision gene therapies. We are currently looking for a talented Research Associate to join our R&D team under the guidance of senior scientists. Joining at this early stage provides the opportunity to help shape our research aims and company culture.
Location
Berkeley, CA
Role Responsibilities
- Implement in vitro screening methodology with guidance from senior scientists
- Design, assemble, and validate screening constructs
- Maintain human cell cultures
- Perform molecular techniques including nucleic acid extraction, qPCR, NGS library prep
- Produce, purify and titer AAV and lentivirus
- Maintain accurate and detailed documentation of activities
- Communicate research findings to the R&D team
Required Qualifications
- BA/BS or MS in biology, neurobiology or related field with 2-3 years relevant research experience
- Strong background in tissue culture and aseptic techniques
- Significant experience with standard molecular biology techniques (PCR, qPCR, DNA/RNA extraction), and molecular cloning techniques (ligation, transformation, gibson, RE digestion)
- Excellent written and oral communication skills
- Proven track record of working in collaborative environments
Preferred Qualifications
- Experience in Lentivirus and AAV production and purification
- Experience with large-scale genetic screening methods
- Experience with single-cell genomics techniques and analysis
Regel Therapeutics is a gene therapy company focused on improving the life of patients suffering from disorders resulting from alteration of gene expression. Our proven T3 (Targeted Therapeutic Technology) platform combines AAV delivery with two proprietary technologies for efficient and specific restoration of gene expression exclusively in the cells affected by the pathology. We are a seed-stage startup based in Cambridge, MA and Berkeley, CA and are looking for a talented Research Associate to join our R&D team and work under the guidance of senior researchers.
Location
Cambridge, MA
Role Responsibilities
- Establish and implement in vivo screening methodology
- Validate hits using histological and molecular biology techniques
- Participate in experimental design
- Maintain accurate and detailed documentation of activities
- Communicate research findings to leadership
Required Qualifications
- BA/BS or MS in biology, neurobiology or related field with 1-3 years relevant research experience in laboratory setting
- Experience with tissue sectioning (e.g. using a vibratome and/or cryostat)
- Experience with immunohistochemistry and microscopy
- Experience with standard molecular biology techniques
- Experience with performing basic experimental analysis
- Excellent written and oral communication skills
- Proven track record of working in collaborative environments
Preferred Qualifications
- Experience with in situ hybridization and/or RNAscope
- Hands-on experience handling mice and with mouse surgical techniques
- Experience with mammalian cell culture
- Previous experience working with AAVs